A GLI3 variant in Denisovans and Neanderthals may have increased polydactyly. Six-fingered figures appear in myths globally—from Native American to Australian Aboriginal traditions. Six-fingered handprints even show up in Chaco Canyon cave paintings, suggesting this trait wasn't always seen as a deformity. The Dilda family in Brazil shows these extra digits can be fully functional! 🧬🖐️
GLI3 gene variant linked to polydactyly in ancient human populations

Key facts
- GLI3 gene variant found in Denisovans and Neanderthals increased occurrence of polydactyly (six fingers and toes)
- Six-fingered/toed figures appear in ancient myths globally, including Native American, Australian Aboriginal, and Turkish (Çatalhöyük region) traditions
- Six-fingered handprints appear in cave paintings at Chaco Canyon, New Mexico, suggesting the trait was not necessarily viewed as a deformity
- The Dilda family in Brazil has functional extra digits on each limb, demonstrating the trait's potential benefits
Sources
pmc.ncbi.nlm.nih.gov
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pmc.ncbi.nlm.nih.gov
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incitefulmed.com
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