A 2023 paper tested a Neanderthal/Denisovan GLI3 variant in mice, finding it caused skeletal deformations including enlarged cranium, twisted ribs, and shortened spines. Despite not affecting direct cell-DNA binding, it triggered profound downstream changes in gene regulation. Depending on the genetic pathway, the variant could produce GCPS, PHS, PAPA—or no change at all. Interbreeding between hominid species could yield either disastrous mutations or beneficial traits! 🐭🧬
2023 study tests Neanderthal/Denisovan GLI3 variant in mice
Key facts
- 2023 paper titled "A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice" tested the specific GLI3 variant on mice
- The variant caused skeletal deformations including polydactyly in mice
- The study demonstrated profound downstream changes despite not affecting communication between cells and their DNA
- Depending on the organism's genetic pathway, the GLI3 variant could produce GCPS, PHS, PAPA, or no change at all
- Interbreeding between hominid species could have produced disastrous mutations or beneficial traits in offspring
Sources
pmc.ncbi.nlm.nih.gov
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pmc.ncbi.nlm.nih.gov
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incitefulmed.com
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radiopaedia.org
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GLI3 in Archaic Humans: Possible Contributions to ...onlinelibrary.wiley.com
We have identified that a GLI3 variant fixed in Neanderthal and Denisovan alters various downstream gene regulations and skeletal structures in ...
A Neanderthal/Denisovan GLI3 variant contributes to ...biorxiv.org
We demonstrate that mice with a Neanderthal/Denisovan GLI3 variant exhibit altered skeletal structures, such as enlarged cranium, altered shapes ...
A Neanderthal/Denisovan GLI3 variant contributes to ...data.mendeley.com
This is the dataset related to the manuscript "A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mce" by Ako Agata, ...
A Neanderthal/Denisovan GLI3 variant contributes to ...scite.ai
Here we investigate the biological effects of a variant of the GLI3 transcription factor (GLI3R1537C) carried in Neanderthals and Denisovans, which are extinct ...
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